It 100% totally depends on the type of bondage.
Are we talking Sex play? Tied spread eagled to the bed with scarves, soft rope, leather cuffs, or other tying mechanism?
Cuffed by your wrists and ankles to a St. Andrews Cross for bdsm play?
Tied with rope on the floor so you can't get out?
Or, a VERY different sensation, your entire body suspended from a rig?
Some people absolutely love being suspended, but this is were the major discomfort comes from, permanent or temporary nerve damage can and does happen when the rigger is unqualified, not knowledgeable, or just plain not careful. The people that LOVE it, are suspended in ways I could not even imagine, but they go right into a subspace. It is about clearing their head and of course sensation and or sexual play.
I have been suspended twice by experience people. it was super painful because the rope cuts into your body and supports your entire weight. I am only about 150 lbs 5'6" and it was not anything I want to try a 3rd time.
I get tied or cuffed frequently to a cross or table or other place, not full body, but definitely restrained.
I personally like light bondage where I still cannot get out but not suspension bondage where I am feeling my own weight on every strand of rope.