I have had a few memorably bad enema experiences. Here are two of them:
One was using Palmolive green dishwashing soap more than twenty years ago. It left me with an extremely sore anus and the urge to push, long after I was completely empty. I never used that again.
One other time, also more than twenty years ago, I was out shopping on a Saturday morning a year or two after we were married and my husband was at work. While in the drug store on the checkout line, I saw all the tins of snuff and chewing tobacco. I thought it would be interesting to make a snuff solution enema to find out what people liked about snuff and chewing tobacco, only I would be using it in a solution up my butt, rather than sniffing it into my nose or chewing it. When I got home that Saturday afternoon, I used about a heaping teaspoon in 2 quarts of warm water and let it steep like tea.
I have never smoked anything in my life -- cigarettes or pot. I hate the smell, the mess and everything about it. The nicotine in the snuff gave me a bit of a buzz during the first couple of minutes, then I felt kind of drunk, then I got all sweaty. After that my ears started ringing and the icing on the cake was I got severe abdominal cramps and so nauseated, I thought I was going to throw up, but since I hadn't eaten in several hours, all I had were dry heaves. I managed to get on the toilet to expel it all and I ended up crawling into bed and sleeping it off for about three hours. Unfortunately, I did this enema on a Saturday afternoon when my husband wasn't home. When I was feeling as bad as I was, I was sorry that he wasn't there to be with me, or at least let me know that I would pull through after my period of suffering. Luckily, this was before we had children. That was another recipe I never did again.