Interesting. My first wife was definitely not into them, thought my interest was perverted, and essentially forbade me to do it. Which didn't go over real well, since it had been an interest of mine long before I met her. We stayed together for many years, me playing solo when she wasn't around, her probably ignoring my interests. We split up, and when I met my 2nd wife, it was in a medfetish context, which as I told her, meant she would get "LOTS of enemas..." she is ok with it, but doesn't particularly enjoy them, although since she is sub in the bedroom, she does what she's told. I like enemas. A lot. Never understood, but I am guessing that it's at least partly because I like having things in my backside. Water is the best, though. A really big enema is a good enema in my view, which does sometimes upset my wife, since she also has to take large enemas (2 qt. plus--not huge, but still...). Something about the nozzle inside and all that water going in...
So in my case, I've given many enemas to my wife, not because she wants them so much, as because she knows doing that gives me pleasure.
I did quite a bit of medical fetish play before I met her, and I ALWAYS gave enemas. I have had a few women refuse to meet with me after they found out about the rectal exams and procedures, but if they met me, they definitely got enemas. I've met a few women who obviously were into them, and some of those enjoyed the humiliation and pain. For others, it was definitely pleasurable. I met with a few men (I'm very straight) just because they sorta begged, but stopped that after a time or two, since I really am not into men at all.
Now my wife...I love her dearly, make her do the play I want, and at the same time try to give her all the intense experience she deserves. Thinking about her literally gives me goosebumps. And no, we're not newlyweds. It's just that every time I'm with her it's such a trip.
BTW: if you want partners who please you, do specific Craigslist ads for what you want. I did. And I got her. Still amazed, after 8 years. If you're with someone, they deserve the chance to understand your sexual interests, and to meet them, whatever they are, even if it's not their favorite thing. We are all way too selfish. Sex is NOT the place for selfishness.