I wonder what you consider to be a large volume? Why?
To me, a large volume enema is any enema over four quarts and I use the four quart volume for my enemas daily. I have taken larger volumes at times and induced nausea by doing so. When I first began to self adiminster, I could not take a full two quart bag so that was a large volume. Later I could take the two quarts and three quarts became a large volume and so on. I have stopped pushing the limit at four quarts because I am fearful of an acquiring a megacolon. I do take my four quarts daily because, an enema a day keeps the doctor away!