Ok, migraines are throbbing headaches, they throb with the heart beat, so do hemmorages in the brain, but that is very very rare. So nothing is absolutely safe.
A throbbing headache, a common migraine, without prodrome, the flashing lights, is most often from a chemical cause:gunpower , chocolate, milk, cheeze, but usually the person has a tendancy to migraines. Some people never have headaches, no matter what they do! Lucky people.
Any way common migraines, a coffee enema helps immensely, should releive the head ache within a few minutes. It does, via the caffine, constrict the arteries, and it can remove the offending chemical if it is in the colon.
Next, classical migraines, those of us lucky enough to have these know them well, you get them regularly till in your 40s usually then they get better. With these you have the prodrome, flashing lights or something that lets you know its comming, within a few minutes you are down with that throbbing headache. A doctor that does manipulation can turn one of these off in about 20 minutes with an adjustment to the upper thoracic spine, the usual source of the vasodilation, and coffee enemas followed by rest, relaxing and heating the upper back can help or fix them too.
The enema works better than taking it orally because you absorb the caffiene about 15 to 20 times faster via colon, then you get rid of it, so it has a faster, larger spike of caffiene and less effect generally, and the headache is usually gone as you go to the bathroom. However, coffee is acidic, can irritate the colon. I neutralize it with baking soda to prevent this, and wash it out with a baking soda or saline enema after the headache is gone.