Bisacodyl added to large enema

I'm working on another possible protocol for tablet use that doesn't involve soap. Will get back to everyone.

Soap is a "no-no" cause it leaves a false positive for early ulcerative colitis. One of our medical professionals told me that just using Bisacodyl is ok..

It is very interesting to know upon this fact.

Bisacodyl is formulated so that the coating dissolves in your large intestine NOT in the stomach.

The way they do that is to make it dissolve in alkaline but not in acid

This is WHY the stomach upset occurs when you take it with something like Hawaiian Punch or Gatorade and NOT if you take it with orange juice or tomato Juice

Suppositories are all about temperature. So if you are a person who's normal body temp i below 98.6 you will need more time for it to start working

Actually the answer is a little more complicated than that. Bisacodyl is actually inactive. Bisacodyl consists of a core molecule with an acetate group on both sides. The active ingredient is the core molecule itself. It is released when the acetate groups fall off the core molecule the large bowel based upon pH . How long that takes is almost entirely a function of the pH in the large bowel. Sodium Picosulfate is the same core molecule but with a Sodium Sulfate in place of the Acetate group. With Sodium Picosulfate it is the colonic bacteria that strip off the Sodium Sulfate from the core molecule to release the active ingredient. So depending upon the pH in the large bowel, in some people Sodium Picosulfate is much more potent than bisacodyl because of the different mechanism involved in the release of the core molecule. Because the colonic bacteria are required to release the active ingredient in Sodium Picosulfate, the drug does not need to be protected. Absent the bacteria, the drug is inactive. It is also water soluble, which means there is no need for a tablet form. It can simply be added to any water based liquid. In most people the mechanism for releasing the active ingredient drug will release significantly more of the core molecule from sodium picosulfate than will be released from Bisacodyl, so sodium picosulfate doses are on average about half the bisacodyl dose.

The coating on the bisacodyl table is an effort to insure that the drug is not released until it reaches the large bowel. Once released the effects are almost entirely dependent on the pH inside the bowel. If the pH isn't 'tilted' far enough, most of the acetate groups remain attached, and with the acetate groups still attached, the drug is inactive.

Interesting, given the mechanism for bisacodyl, then adding a couple of tablespoons of sodium bicarbonate to the enema mixture should strip the acetate groups, and activate the core molecule.

I've been wanting to give my husband a 2 liter coffee enema with 20mg of Bisacodyl added in. I'd plug him up with an inflatable plug and make a bet with him to see how long he can retain it. 😃

Has anyone tried Bisacodyl with a large coffee enema?

It would be the same or similar to bisacodyl in a water enema. If you soak the pills well or use Magic Bullets I'd give him 15-20 minutes, maybe even less, before he's doing his best to get you to let him go to the toilet.

With 20 mg of bisacodyl, i think the over/under bet would be about 10 minutes, it sure is with me.

I tried 20mg with some soap in a Fleet bottle once as a pre enema enema. It was kicking in before I could fill the bag and take the full 2 quart soapsuds. I was able to get the 2 quarts hot and soapy in on top of the bisacodyl, but didn't hold it long.

Actually the answer is a little more complicated than that. Bisacodyl is actually inactive. Bisacodyl consists of a core molecule with an acetate group on both sides. The active ingredient is the core molecule itself. It is released when the acetate groups fall off the core molecule the large bowel based upon pH . How long that takes is almost entirely a function of the pH in the large bowel.

That was actually a very well done reply and probably gets into more detail than the average person needs to know but I thought it was fascinating. We use similar chemicals with molecules stripped off and others added for longevity that is now being scrutinized by various government agencies that will no doubt to further rules and banned chemicals. Great job.

The acetates are stripped off at higher pH levels, right?

Yes, that is why i thought one could mix baking soda with the bisacodyl tabs and activate the molecule. i tried that and it did not seem to work, after ten minutes, 20 mg of bisacodyl did nothing. ten minutes with a castile soap/20 mg. of bisacodyl enema is a lot of cramps. i will continue to work on this.

Understand that the coating on oral bisacodyl is designed to dissolve in an ALKALINE environment not an acid one.

The secret to oral bisacodyl is to stick to things like orange juice during your pre-enema fast. If you use things like apple juice which is basically alkaline, the bisacodyl can dissolve in your stomach, and when it does high doses like 30 mg will tie your stomach in knots. before it ever reaches the large intestine.

Keep in mind that the stomach releases part of it's content into the small intestine about every 20 minutes. Likewise the small intestine releases part of it's contents into the large intestine at a similar rate.

Fasting slows that release from the stomach to the small intestine, if the stomach is really empty it's mostly water.

Essentially the stimulation it causes in the large intestine DOES cause the small intestine to release more often than it normally would.

So one way to clear your system is to clear the stomach by fasting the lower bowel wit enemas and then the small intestine with a saline laxative like magnesium citrate or milk of magnesia, then the bisacodyl, when it DOES kick in clears out anything remaining or any left over soapsuds from the enema

Soaking the tablets in a small squirt of Bronner's Peppermint is highly effective.

Last night I took two bisicodyl suppositories and held them for 2 hours, then released. Immediately following I took a 3 and 1/2 quart very warm enema with a 3 tablespoons of peppermint soap. The cramps were almost unbearable, and when I released the peristalsis was SO strong, I was pushing and pushing well after I was totally empty, and had that totally clean feeling afterward. It was wonderful.

Sounds like a fun enema

Generic Bisacodyl tablets are very cheap and when crushed in a pill crusher, then added to some warm soapy water make a great enema. The cramps are enhanced by the combination and it gushes out as soon as I sit or squat to expel it.

I have been running experiments comparing bisacodyl from magic bullet suppositories, and bisacodyl from tabs that have been broken apart by soapy water. In both cases i used 2.2 quart enemas, double balloon catheter, with 20 mg of bisacodyl. Flow rates were the same, administering the enema in 6 minutes. The enema with the magic bullet sourced bisacodyl not only starts cramping earlier, 6 minutes vs. about 9 minutes, but is also a much stronger enema- no concrete data, just the feelings, the urge @ 11 minutes in the magic bullet case is much stronger, than the bisacodyl enema using tabs. i have run the experiment twice, same result. Thoughts as to the reason for this result??

Bisacodyl certainly increases the power of an enema.

I've tried it a couple of ways. Firstly, by crushing/grinding up 4 Dulcolax pills and dissolving them in a few ounces of warm water. In my experience, the pills never fully dissolve, even if some bicarbonate of soda is added. I guess that has been suggested because the pills are coated to pass through a person's acid stomach, undissolved. The coating dissolves in the alkaline colon, releasing the laxative chemical and making the person poo.

I really prefer the Magic Bullet suppositories. They use a base that readily dissolves in warm water within a minute or two and the solution can easily be added to a bag of warm water.

Magic Bullets are not the same as Dulcolax or generic suppositories. which use an oily base.

In water they may melt, but do not dissolve.

One Magic Bullet is supposed to be the same as two 5mg pills.

My preference is to use only one suppository in 1000ml to 1500ml of warm water. For me, that produces a very strong evacuation, but doesn't have to be given so quickly as to cause pain.

Make the solution too strong and you will start to poo before all the solution is taken.

If you like intense cramping, this is worth a try. Get a Fleet (or generic) Mineral Oil Enema and put it in warm water to heat the oil. Drop one or two Dulcolax suppositories into the warm oil and allow then to melt completely. Then administer in the knee-chest position preferably.

The urge will build rapidly, usually without letup, and the lubricated poo is pretty much impossible to hold long. This enema causes messy accidents.

Have fun

When I am able to get the Fleet Bisacodyl mini enema, and I am doing a full cleanse, I get into position a few minutes early and take it 10 to 15 minutes before the bag enema

In the previous post about adding Bisacodyl (Dulcolax) to enemas to increase the potency, I neglected to mention one thing.

In a patent for a bowel prep, it is suggested to add both Bisacodyl and Castile Soap to the water, the theory being that the soap brings the Bisacodyl into closer contact with the bowel wall, causing even more rapid and intense laxative effects. It is an interesting theory and makes some sense, but I've never tried it.

The intent was to concoct an enema that would rapidly and completely clean someone out before an x-ray or colonoscopy, without fasting, repeated laxatives, suppositories, etc. One extra powerful enema would make someone completely clean in under 15 minutes. BTW, it was intended to be administered with nozzle that really plugged the patient, I suspect because the enema would be nearly impossible to retain with out help.

I have no idea if it was ever used, but seems interesting.

Actually the mixture of bisacodyl and docusate would probably work better than soap and bisacodyl. Docusate is a detergent that is approved for internal use. It can dissolve the layer that separates the colonic contents from the nerve endings. In Australia there used to be product that was a highly concentrated docusate solution, something on the order of 50 grams in 100ml of liquid. It was intended for use as a enema after being diluted 18:1. Let's just say at that dilution it was impossible to hold for more than a few minutes. For this to work you would need about 10 grams of docusate per liter of water (that is 1%, which is a much lower concentration than the 18:1 described above, but 18:1 is far more docusate than is needed).

One enema that will clean you out very well after one enema is Susie's Very Rough Ride Enema.

SIX magic bullets, two ounces of peppermint extract, a pint of glycerine, four ounces of soap and water to make two quarts of solution. Try it if you dare.

https://en.zity.biz/index.php?mx=forum;ox=display;topic=102932;mark=susie%27s%2Cvery%2Crough

I'll pass on that one Susie, I couldn't hold a pint of that for 5 mins.

The Very Rough Ride is a strong one. Definitely cleans you out, but it took me a full 24 hours to recover from it.

I don't know that I would do it again on my own for fun. Maybe if I had a partner who wanted to put me through it, but it is very strong and doesn't stop for hours even after it is "all out" - courtesy of the bisacodyl and glycerin.

I do put more "ordinary" concentrations of bisacodyl in a soapy enema now and then when I want a good cleaning out or my bowels are really obstinate, or I slip in one or two bisacodyl suppositories 10-15 minutes before taking a soapy enema. Both work much better than the enema alone, but you feel the bisacodyl working for about 30-60 minutes after the enema comes out and it makes taking a rinse more difficult during that time.

Lately been starting with Fleet enema, then depending on how much time i have, I’ll follow up with bisacodyl suppositories either 1 or 2 wait 15-20 min then take a J& J baby shampoo enema. Hold it as long as i can then expel. Rinse and repeat several times until I feel empty

I have tried tablets in my enemas and they have never done anything for me.

I just ordered some Bisacodyl pills and some suppositories. I have taken the pills in the past to get things going and move stuff out of my small intestine. I have taken a couple all the way up to 8 at one time.

Now, if I use suppositories, insert them wait some and then start a very warm enema, which will clean me out quick? That is my question,

So that will provide a rather explosive enema! I just want to try it.

Matthew50 had the best solution. Put 2-3 Dulcolax tabs into a shot glass of NaCo3 and let it dissolve. Add that solution to an 8 oz. bulb syringe and inject it. Take a 2 qt. tap water enema at once to drive the Dulcolax liquid up high into the colon. Within 7 minutes the Dulcolax will activate and give you an explosive expulsiion It will clean you out like never before.

The bisacodyl tablets need to be crushed in a pill crusher. Generic bisacodyl and pill crusher are cheap at Walmart. Try 6 to start. I use eight or ten. I do this enema using a colon tube to get it in deep. Then I or my girlfriend insert an anal vibrator after removing the tube and the fun starts. The cramps start soon but the vibration in my anus make for an incredibly pleasurable uncomfortably crampy experience.

This is really a variant of the "Clayton" enema that has a separate thread here. Bisacodyl and soap in the solution. I find that three magic bullet suppositories dissolved in two quarts of warm water, with one to two Tbsp of Dr. Bronner's makes for a very thorough clean-out.... moderately crampy, highly effective. After the first expulsion, there will be at least one maybe two waves of additional peristalsis. A plain water "rinse" after that will be almost completely clear.