@paula said
I was at my local store getting some last minute things for our house party last night. So l was in the pharmacy area picking up a few things and did a drive by down the enema area. I noticed a new shelf item that l had seen advertised on tv. It is Biscadol Liquid, cherry flavor. Supposed to work in as fast as 20 minutes.
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@LISAK said
I am curious as to whether or not there is a way to get bisacodyl into an oral liquid.
Here is the issue: Bisacodyl is a stimulant laxative that does its thing by irritating the walls of the intestine.
As a result you DON'T want it releasing into the stomach!
The basic 5 mg bisacodyl tablet actually is actually "tricked out" not to release into The human stomach is actually quite an acid environment. the large intestine is a somewhat alkaline environment. Bisacodyl has a special coating that is made to dissolve in alkaline but not in acid. As a result it normally does not dissolve in the stomach, only in the large intestine. That's why it behaves the way it does. When taken on an empty stomach. it takes a while to work. at least 4 hours, often more, but when it goes to work it's all at once, and it's over in an hour and a half!!
Also that is why you can have problems if you take it with something like grape juice, tropical fruit punch or too soon after any antacid, or anything that reduces the acidity of the stomach.
Maybe there is a way, or will some day be a way to solve that problem in an oral liquid, but right now, if there IS such a solution it is either cost prohibitive or has too many issues!!
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The generic chemical in Dulcolax brand suppositories and tablets is BISACODYL.
That is how it is spelled and the fact that the original poster stated BISACODYL (although she incorrectly spelled it Biscadol which has since been corrected by mods, as was the thread title) means she was erroneous and/or referring to the bisacodyl product (PICO LIQUID) and NOT the Magnesium/milk of magnesia product various posters mentioned.
Dulcolax is the BRAND NAME for number of different laxative products. The Dulcolax line included laxative suppositories, stool softeners, and tablets.
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If anyone had looked up the ingredients for the new Dulcolax liquid, they would have seen the only similarity among the Dulcolax tablets and suppositories and the new Dulcolax liquid is the BRAND NAME.
The discussion about how they got the new liquid Dulcolax to be OK in the stomach is an ERRONEOUS and MOOT POINT because they DO NOT CONTAIN THE SAME INGREDIENTS as the Dulcolax brand tablets and suppositories.
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The Dulcolax suppositories contain 10 mg and the tablets contain 5 mg of bisacodyl among a list of inactive ingredients.
Following either oral or rectal administration, bisacodyl is rapidly hydrolyzed to the active principle bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM), mainly by esterases of the enteric mucosa.
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The active ingredient in the new Dulcolax pico liquid is sodium picosulfate, among a list of inactive ingredients.
Sodium picosulfate is converted into the active laxative compound, bis-(p- hydroxyphenyl)-pyridyl-2-methane (BHPM), via bacterial cleavage in the distal segment of the intestine.
And that my friends, is how the new pico liquid Dulcolax is OK in the stomach and is NOT the milk of magnesia equivalent. 😎 😎 😎
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There is no such thing as Biscadol. Due to that original error, people were comparing apples and oranges and people did not recognize that.
You have to be careful when taking, discussing or recommending drugs and SPELLING COUNTS.