These are exciting times in the study of sexual response. Not long ago John Steinbeck could say that the typical American man knew “more about the Ford coil than the clitoris.” Now, recent advances in brain imaging are helping scientists draw the schematic that links the clitoris to the biggest sex organ of all: the brain. Komisaruk is at the forefront of that research. Born and raised in the Bronx, the son of Eastern European immigrants who ran a humble Harlem pharmacy, he received a doctorate in neuroscience at Rutgers and began his career studying the pleasure centers of rats at UNCLA’s Brain Research Institute.
When he became a professor at Rutgers, Komisaruk noticed an odd thing: Horny rats don’t appear to feel pain. He decided to see if the same was true of horny humans – but he ran into fierce resistance from opponents who thought that kind of research would damage the university’s reputation. About the same time in 1982, Komisaruk’s wife died from cancer. “It was a very very difficult year”, he remembers. “She was in the hospital in terrible pain. And I felt like a dummy just standing there not being able to do anything for her.”
Freshly determined to make pain relief his mission, Komisaruk finally received the university’s permission and began the first series of human tests to explore the neurology of orgasm. Working with a graduate student named Beverly Whipple (now one of the world’s foremost researchers on the science of sex), he quickly established that vaginal stimulation in women increased pain threshold by 50 percent. Orgasm was the ultimate painkiller, raising the pain threshold to 100 percent – but not for men. Despite the powerful effect orgasm had on women, it had no effect on male pain. Komisaruk and Whipple learned this was because male orgasm is carried exclusively through the pudendal nerve (which doesn’t carry inhibitors for pain), while female orgasm also travels through the pelvic nerve (which does). They even discovered that a specific peptide produced by the pelvic nerve creates the pain-blocking effect, which Komisaruk was able to simplify and patent. Then he began focusing on orgasms in women with spinal cord injuries. Since their pedendal nerves were usually severed, these women provided him a clear picture of which nerve pathways sexual information rides on it’s way to the female brain.
With the data from this research Komisaruk was able to produce the first detailed map of the female sexual response system, proof of what folk wisdom had said all along: Men are simple, and women are very complicated. “We now know there are three different nerves, each of which can by itself activate an orgasm in women”, he says. “We also know that the more nerves that are stimulated the more complex and intense the orgasm becomes. Clitoral seems more external and localized, and vaginal or cervical feels deeper and incorporates the whole body. In other words, they’re additive.”
The final step was to chart the stimulated parts of the brain with brain scan imagery, a technique that became available only five years ago. The orgasm centers turned out to be the nucleus accumbens (which also plays a role in laughter, addiction and fear), the amygdala (which tells the adrenal gland to produce adrenalin), the insular cortex (which translated sensations into emotions such as happiness and disgust) and the hypothalamic region (which plays an important role in childbirth and produces the mysterious hormone oxytocin). Again all the evidence confirmed folk wisdom: At the level of brain chemistry, women really do feel a connection between love and sex. From Playboy Magazine 2010.
Many experienced enema users both males and females on this Forum, have reported experiencing the strongest orgasms after achieving the fullest enemas possible. Sometimes this has been assisted by manual stimulation during a period of retention, and sometimes after expulsion on the toilet. Less frequently “hands free” orgasms have occurred for both males and females.
The sexually stimulating effects are more easily explained in the case of males by the pressure of the distended anal canal on the prostate gland. The larger the enema, the larger the distension and pressure will be, and the more likely a spontaneous ejaculation will occur.
The sexually stimulating effects of large volume enemas for females is less clear. Is it caused by the release of serotonin from the colon into the circulation and then transported to the brain, leading to euphoria and tranquilizing and sleep inducing effect? If this is the case, then this would apply equally to males.
Is it due to stimulation of the elusive G-stop? Some females report enjoying a level of cramping which can be increased during a prolonged period of retention.
I would be interested in comments concerning the article from Playboy Magazine and my own theories concerning enhanced orgasms, from both males and females on this forum.