As other have mentioned , these energy drink containing stimulant drugs, chiefly caffeine, which is marketed as providing mental and physical stimulation. When consumed in large amounts caffeine consumption greater than 400 mg include nervousness, irritability, sleeplessness, increased urination, abnormal heart rhythms (arrhythmia), and dyspepsia.
So as you can see an energy drink enema could potentially be fatal , so I would recommend that you do not attempt such a dangerous procedure. I seen a few people needing cardiac monitoring from drinking too much of these energy drinks.
As liquidsky stated:
I would just advise--be careful about drinking multiple energy drinks back to back. I once saw a 22year old who'd had a cardiac arrest following three such drinks in a short period of time. His family knew CPR and kept him alive somehow until I was able to defibrillate him. I was sure he was a goner but he made it.
Unless you can perform CPR on a partner or your partner can perform it on you then don't try this, even in hospital CPR is not always successful.
If you combine energy drinks with alcohol can mask the influence of alcohol, and a person may misinterpret their actual level of intoxication. Since caffeine and alcohol are both diuretics, combined use increases the risk of dehydration, and the mixture of a stimulant (caffeine) and depressant (alcohol) sends contradictory messages to the nervous system and can lead to increased heart rate and palpitations.
Excessive or repeated consumption of energy drinks can lead to cardiac problems, such as arrhythmias and heart attacks, and psychiatric conditions such as anxiety and phobias. In Europe, energy drinks containing taurine and caffeine have been associated with the deaths of athletes.