Melatonin suppositories

Hi. I have recently embarked on a get healthy and back in shape adventure. Weight loss and fitness is at the forefront of my goals. Recently I started experiencing some insomnia issues, which many people including professionals said, could be just a normal part of the weight loss and fasting processes. I am extremely tired during the day and at night I can’t sleep. Now I came across an article about melatonin and how in large dosages administered rectally it helps people to sleep. If anyone has heard about this or has experience, I would be very curious. I found several websites that sell melatonin suppositories, so procurement won’t be the issue. I am left wondering if this is just a fad or if there is some substantial science and evidence behind the theory

It's an interesting thought, and I know nothing about the matter. I think a key question is whether melatonin is particularly well absorbed by the colon & rectum. Hopefully somebody reading this thread knows the answer.

Apparently it’s better absorbed via the rectal route. Suppositories give a slow release. The dude whose article I read says he takes them in 300mg Dosis - which is extremely high.

Article link?

@DeDude,

I’m a retired US doctor and also take melatonin for bad insomnia since about 2015. Why take it rectally unless you simply would enjoy the ano-rectal stimulation from insertion? Do the rectal melatonin suppositories list a dose on the bottle or packaging? Where did you read that the drug is better absorbed rectally?

Eric

@ericmacson in the discussion the dose was very high, 300mg to be exact. Apparently taking it orally isn’t great because of the first pass effect. He said he takes 300mg suppositories because it has higher bioavailability and its slow absorption over longer period of time. He claimed the effect lasted all night and longer. Like I said, I’m looking into the claim: some meds work differently when taken via the bum.

Can you please share the link to the article where you read this up? This is indeed interesting. However I have my reservations about the efficacy of this practice. Not to mention there is a chance of someone getting addicted to melatonin suppositories leading to drug abuse.

There are various articles about the use of rectal melatonin for I S, cancer and sleep. A company called Zetpil makes pretty high dosage melatonin suppositories. Here is the link https://www.zetpilnutrition.com/product/zetpil-melatonin-400mg-sr-suppository/?srsltid=AfmBOooAY_G1bqaQkHTZ12MB1pBOKcgkQb9pup58O1u1M3AteroAl_Uo. There are other articles too, claiming a wide variety of applications. Honestly, I myself am skeptical about how effective and accurate this data and reports are.

I have heard about a company that make suppositorie (I think for vaginal use) with herbs to help you sleep

They are called Hello Again and they are supposed to be very potent. The thought is very sexual to me tbh but that's just me lol

There are various articles about the use of rectal melatonin for I S, cancer and sleep. A company called Zetpil makes pretty high dosage melatonin suppositories. Here is the link https://www.zetpilnutrition.com/product/zetpil-melatonin-400mg-sr-suppository/?srsltid=AfmBOooAY_G1bqaQkHTZ12MB1pBOKcgkQb9pup58O1u1M3AteroAl_Uo. There are other articles too, claiming a wide variety of applications. Honestly, I myself am skeptical about how effective and accurate this data and reports are.

I am wondering why they've used the Dutch word for suppository for their brand's name 😉