Uncut here. This is an interesting question, simple in its ask, that I pondered deeply about. I would say the upshot of being uncircumcised is simply knowing that I have an intact penis and any of the good that comes out of that. While discussing foreskins and circumcision is a keen interest of mine, I feel lucky to have kept mine (I would have been circumcised if not for being born over two months prematurely). Not worrying about what could have been, or struggling with issues regarding my own bodily autonomy.
Example: If the literature out there is to believed, then I have higher sensitivity because of full innervation of the penis; everything is there. Additionally, partners may also find intercourse with me more comfortable because of the gliding motion of the foreskin, which is itself very pleasurable for me, too. (Masturbating without ever needing lube!) But: since much of the data out there are self-reported and so many circumcised men (and their partners) say they have awesome sex, then who am I to judge? I have no complaints about the function of my penis and very much relish what I can get out of it. My most recent partner has had all circumcised dicks before me, and says she's never had bad sex. She truly enjoys the sex she has with me and thinks foreskin makes a big difference compared to her past experiences. But again, the emotional and the physical work together in human sexual response.
The downside? Being in the US, with a majority of men circumcised (especially of my generation), I do not have the highest confidence in what women might think of it. This started with my mother telling me as a child that my penis had unusually long foreskin and that if I wanted to get cut, she'd pay for it. Even in my sample size of about seven partners, of which all of them were neutral or favorable to my penis/foreskin, the cultural conditioning is so strong that it still makes me worry.
Regarding hygiene, well, that's a wash, pun intended. People need to shower and clean everywhere, no if's/and's/but's. Appearance-wise, maybe the long foreskin is a turn off when soft, but once it's pulled back, particularly when erect, most women can't tell a difference anyway...