@AbleBaker as someone who works in Endoscopy you can tell any patient that regularly takes enemas as the colon will show sins of Melanosis Coli. Melanosis coli is a medical condition caused by the release of a pigment molecule — called lipofuscin — into the mucus membranes of the large intestine (colon). The most common way that it’s discovered is through a colonoscopy, a test that is used to detect polyps or other irregularities in the colon.
Melanosis coli causes a dark brown mucosal pigmentation in the proximal colon, which refers to the beginning portion of the large intestine that connects to the small intestine and the middle regions of the large intestine. However, there are some reported cases where the coloration was almost black in color.
Most patients with melanosis coli also have increased rates of polyps in their colon. Polyps are cell growths that come out of the mucus lining and are typically not harmful. It is unclear how melanosis coli is linked to this increased rate of colon polyps.
There's question as to whether increased polyps is a true symptom of melanosis coli. The increased rate of polyp detection could be due to the darker intestinal coloration that melanosis coli causes. This coloration change makes polyps easier to see in a colonoscopy.
There's some evidence of increased rates of adenomas — non-cancerous tumors — in patients with melanosis coli. In general, these are not a cause for alarm. More research is needed to determine if this condition is simply a change in coloration or a sign of deeper problems and chronic injury to the colon.
Melanosis coli is most often seen in people ages 45 and older. But anyone who uses laxatives for more than a few months at a time may develop the condition. It’s seen equally in men and women. The particular kinds of laxatives that lead to melanosis coli contain sennosides, which are found in rhubarb and the senna plant. These types of over-the-counter herbal laxatives don’t become active until they have passed into the large intestine. Once active, they cause damage to the mucus lining and the cells die. This cell death creates the dark pigment that is seen in colonoscopies. Other cells in your body eventually clean up these dead cells. Osmotic or diphenolic laxatives are not associated with melanosis coli.